May 2025

Peer Reviewed Feature Articles
Women’s health

Premature ovarian insufficiency: recommendations from the new guidelines

Amanda J. Vincent, Carolyn Ee

Premature ovarian insufficiency should be considered in women younger than 40 years of age with four months or more of menstrual disturbance. It is associated with an increased risk of multimorbidity, such as osteoporosis, cardiovascular disease, infertility and decreased survival. Personalised hormone therapy is the mainstay of treatment and should be initiated promptly and continued until at least the usual age of menopause to minimise the risk of long-term sequelae.

Peer Reviewed Regular Series
Perspectives

Nonsurgical treatment of thyroid nodules – the rise of thyroid ablation

Catherine F. Sinclair

Thyroid ablation can be used to shrink symptomatic thyroid nodules without surgery and allows patients to avoid thyroid hormone replacement therapy postprocedure. Appropriate selection and counselling of patients by a thyroid specialist are vital in ensuring optimal outcomes.

Perspectives

Improving outcomes for people with diabetes-related foot disease

Stephanie Baddock, Joel Lasschuit

Foot disease is a common complication of diabetes that can have serious consequences, including amputation or death, without early detection and skilled management. Regular diabetes foot assessment and referral to a high-risk foot service when indicated can greatly improve outcomes.

Physician-authored summaries and commentary on the most important medical research, provided by the NEJM Group, a division of the Massachusetts Medical Society.

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