Peer Reviewed Feature Articles
Endocrinology and metabolism

Androgen replacement in men. Maximising efficacy, minimising adverse effects

Nandini Shankara-narayana, Ann Conway
There is no evidence of benefit from testosterone replacement therapy in chronic disease, ageing or obesity, and no justification for trialling it. A definitive diagnosis of hypogonadism is required before starting and carefully monitoring lifelong therapy.
Endocrinology and metabolism

Secondary fracture prevention. Ensuring the first fracture is the last

Kirtan Ganda, Markus J. Seibel
People who have sustained a minimal trauma fracture are at increased risk of secondary fractures. A systematic, co-ordinated approach is key to secondary fracture prevention and involves risk factor assessment and use of pharmacological and nonpharmacological therapies.
Peer Reviewed Regular Series
Perspectives

Type 2 diabetes and multimorbidity. Factors affecting decision-making

Rita Mcmorrow, Jason Chiang, Gary Kilov, Ralph Audehm, Jo-Anne Manski-nankervis
Shared decision-making that prioritises the patient’s goals is recommended when treating a person with multimorbidity. Management requires consideration of prescribing choices that benefit concordant conditions.
Perspectives

Pancreas and islet transplantation in diabetes. Who is eligible?

Heather Burns, Charmaine Cheung, Jenny E. Gunton
Pancreas and islet transplantation offer recipients greatly improved quality of life and the possibility of a cure of diabetes. Suitability criteria and long-term burden of immunosuppression for each transplant differ and should be considered for eligible patients.