Investigations in endocrinology

Investigation of hyperprolactinaemia

Investigations in endocrinology

Investigation of hyperprolactinaemia

Nadia Manzoor, Ann McCormack

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Abstract

Investigation of high prolactin levels in a man with muscle weakness and decreased libido, a woman with schizophrenia, and a young woman with oligomenorrhoea and acne is described in this article.

Article Extract

The primary action of prolactin is to assist in the development and maturation of the breast and stimulate lactation. Prolactin is secreted by lactrotroph cells in the anterior pituitary gland and is mainly under inhibitory control by dopamine, which is produced by the hypothalamus. Thyrotrophin-releasing hormone (TRH), oestrogen and vasoactive intestinal peptide stimulate secretion of prolactin.